It ain’t necessarily so…

To the Editor:

I have read with interest the case report by Azem et al. (1), and congratulate them. However, several points need clarification:

Evidence-based medicine or just a theory?

To the Editor:

Recent correspondence in this journal (1,2) renewed interest in GnRH agonist therapy as an “ovarian protectant” in female patients undergoing chemotherapy. Do we have evidence-based data to recommend this treatment? Twenty-eight years ago the concept was first introduced. One would expect an “evidence-based” answer to the question, by now. After all, this is a classic question that can only be answered by a multi-center, randomized prospective study.

Do we have the answer?