It ain’t necessarily so…

To the Editor:

I have read with interest the case report by Azem et al. (1), and congratulate them. However, several points need clarification:

IVM of immature oocytes in stimulated cycles

Johnson et al’s (1) efforts to rescue and utilize immature oocytes generated during ovarian stimulation cycles which would otherwise be wasted are commendable. This author’s experience in a similar endeavor (2) suggests that ovarian stimulation regimes may generate approximately 20% immature oocytes (1, 2), which is a significant loss if efforts are not made to rescue and utilize them.

Effect of a phosphodiesterase type 3 inhibitor in oocyte maturation medium on subsequent mouse embryo development

To the Editor:

Jee et al. (1) report that in their hands a prematuration culture using a phosphodiesterase type 3 (PDE3) inhibitor does not improve developmental competence of immature oocytes. We and others previously reported a beneficial effect of this system (2-6). Fundamental differences in experimental design between their work and ours may explain this discrepancy.