Effect of a phosphodiesterase type 3 inhibitor in oocyte maturation medium on subsequent mouse embryo development

30 10 2008

To the Editor:

Jee et al. (1) report that in their hands a prematuration culture using a phosphodiesterase type 3 (PDE3) inhibitor does not improve developmental competence of immature oocytes. We and others previously reported a beneficial effect of this system (2-6). Fundamental differences in experimental design between their work and ours may explain this discrepancy. Read the rest of this entry »

Advertisements




Xenografting fresh and cryopreserved human ovarian tissue (revised 10-31-08)

30 10 2008

 

To the Editor:

In a recent article by Schubert et al. (1), human ovarian cortical samples obtained from benign ovarian cysts were xenografted into SCID mice subcutaneously as either fresh or frozen-thawed pieces . Follicle counts in the grafts and their E2 production as a measure of endocrine function were assessed. While recognizing their valuable work and previous contributions to the field, there are certain points in their study that need to be clarified to the readers.  Read the rest of this entry »





Correlation between DNA damage and sperm parameters:

30 10 2008

 

 

 

To the Editor:

 

We would like to thank Dr. Cohen-Bacrie et al for their fine article (1). In this study, they found that sperm DNA damage was correlated with patient age and some sperm parameters, such as total motile sperm count, rapid progression, vitality, and percentage of atypical forms, abnormal necks and coiled tails. However, there was no correlation between sperm DNA damage and number of motile and atypical spermatozoa per ejaculate, progressive motility after 1 hour and amplitude of lateral head displacement, number of spermatozoa with abnormal basal piece or circular flagella, semen volume and sperm concentration, semen pH, morphology of head, acrosome, and intermediate piece, variation of sperm agglutination factors, presence of leukocytes and polynuclear cells in the ejaculated sperm. Read the rest of this entry »





Effect of sibutramine on weight reduction in women with polycystic ovary syndrome:a randomized, double-blind, placebo-controlled trial

30 10 2008

 

 

To the Editor:

 

 

We have read with great interest the well-designed study by Lindholm et al. (1) and we would like to comment on the potential relationship between weight reduction and insulin resistance (IR) in women with polycystic ovary syndrome (PCOS) treated with sibutramine. Read the rest of this entry »





Ovarian hyperstimulation after a short course of an oral contraceptive in a patient with premature ovarian failure

30 10 2008

 

To the Editor:

 

The paper by Brahma and Kallen (1) about ovarian stimulation after a short course of oral contraceptives in a woman with premature ovarian failure is one of many anecdotal observations that report pregnancies under similar conditions. In my practice I have observed several such cases. Read the rest of this entry »





Less may, indeed, be less: multi-collinearity in studies of ovarian reserve

30 10 2008

To the Editor:

We read with interest the recent paper by Pal et al. (1), in which they conclude that their data and accruing literature suggest adverse influences of “excess” gonadotropin use on IVF outcomes. While we applaud their attempt at tackling a potentially very important question, we disagree with interpretation of data and conclusions in the manuscript. Read the rest of this entry »





Lack of clinical and scientific evidence to justify the systematic use of ICSI in HIV-serodiscordant couples wishing to conceive where the male partner is infected

30 10 2008

 

To the Editor:

 

Sauer et al. (1) reported, in a recent Fertility and Sterility issue, 10 years’ experience of an ICSI program in 181 HIV-serodiscordant couples. One hundred three deliveries were reported. It’s noteworthy that the multiple pregnancy (MP) rate was 41%, and 43% of infants were born preterm. Twenty-one infants weighed less than 1500 grams. No female HIV-seroconversions occurred. Read the rest of this entry »