Premature ovarian failure and dehydroepiandrosterone

26 11 2008

To the Editor:

We were very pleased to read the report by Mamas & Mamas (1), which reported success with  dehydroepiandrosterone (DHEA) treatment in women with premature ovarian senescence. Considering some of the questions such treatment has generated in the profession when we previously reported a series of controlled studies on DHEA supplementation (2-5), it is, however, of crucial importance that appropriate terminology be used when DHEA results are reported. Read the rest of this entry »

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Endometrin for luteal phase support in a randomized, controlled, open-label, prospective in-vitro fertilization trial using a combination of Menopur and Bravelle for controlled ovarian hyperstimulation

26 11 2008

To the Editor:

I read with interest the article by Doody, et al (1). The literature support for the need for luteal support in IVF was presented by Daya and Gunby.(2) A recent reanalysis (3) of this meta-analysis suggests the use of vaginal progesterone to be as effective as IM Progesterone. In order to better understand this publication I seek a few points of clarification. Read the rest of this entry »





Kabuki syndrome and sex chromosomal anomalies: Is it really an association?

25 11 2008

 

To the Editor:

Kabuki syndrome (KS), described by Niikawa (1) and Kuroki (2), occurs in about 1 in 32,000 newborns (3) and is characterized by specific facial dysmorphism, mild to moderate mental retardation, short stature, skeletal abnormalities, prominent fingertip pads and a probably autosomal dominant inheritance. The patients that partially overlap these manifestations are included in the KS-like phenotype group. Up to now, no genetic basis was established, even if several cytogenetic abnormalities detected by karyotype, CGH and FISH have been reported. In particular, an association with different sex chromosomal anomalies (SCA) was reported. Read the rest of this entry »





Evidence of absence or absence of evidence? A reanalysis of the effects of low-dose aspirin in in-vitro fertilization

21 11 2008

To the Editor:

We read with respect the article by Ruopp et al. (1) that has questioned the methodological approach of our previously published review (2) on the use of aspirin in in vitro fertilization cycles. We disagree with the authors in that random-effects models should only be used in the absence of inter-study heterogeneity. With fixed-effects models, it is assumed that there is a sole common effect estimates for all studies, i.e., the true effect of treatment, in both magnitude and direction, is the same value in every study. Read the rest of this entry »





Mathematical models used to determine sperm donor limits for infertility treatment

21 11 2008

 

To the Editor:

In the August 2008 issue of Fertility and Sterility, Sawyer and McDonald provide a useful and insightful review of mathematical models used to determine sperm donor birth limits (1).  The review is timely, given recent policy deliberations around gamete-donation.  Read the rest of this entry »





Hysteroscopic resection of the uterine septum: Is it always a necessity ?

4 11 2008

 

To the Editor:

The article by Mollo et al. (1) reporting the benefit of hysteroscopic septum resection supports the recent literature about the topic. We congratulate the authors for their contribution to the relevant literature. Read the rest of this entry »





Oligo-ovulation or anovulation and hyperandrogenemia contribute to the decreased serum adiponectin levels in normal weight women with PCOS, besides obesity and insulin resistance.

3 11 2008

To the Editor:

We have read with great interest the excellent and well-designed study by Aroda et al. (1). We would like to comment on the potential relationship between serum adiponectin levels, obesity and insulin resistance (IR) in women with polycystic ovary syndrome (PCOS).  Read the rest of this entry »