The effect of surgical treatment for endometrioma on in vitro fertilization outcomes: a systematic review and meta-analysis

29 12 2008

To the Editor:

We read with interest the review by Tsoumpou et al (1) that continues the debate on the surgical treatment of endometrioma and the effect of such surgery on the outcome of assisted reproductive techniques (ART). Read the rest of this entry »

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Association of the protein Z intron F G79A gene polymorphism with recurrent pregnancy loss

17 12 2008

To the Editor:

We have read with great interest the study by Dossenbach-Glaninger et al demonstrating a significant association between the protein-Z (PZ) intron 79G allele and recurrent pregnancy loss (1). In a recent study of 51 women with recurrent early pregnancy loss vs. 47 control women with at least one successful pregnancy and no spontaneous abortions, this finding was not confirmed (2); however, a significant association between low PZ levels and recurrent pregnancy loss was observed, in agreement with a previous larger-scale study (3). Read the rest of this entry »





Use of the levonorgestrel-releasing intrauterine system in breast cancer patients

9 12 2008

To the Editor:

The observational study by Trinh et al.(1) concludes that there is a higher recurrence rate when breast cancers are detected during the use of a LNG-IUS and when it is not removed after diagnosis. Although the authors mainly generate several hypotheses around their observations, we would like to warn about  inappropriate interpretation of their data and premature conclusions, as such a message was released in a couple of Belgian newspapers recently.(2) Read the rest of this entry »





The evaluation of endothelial function with flow mediated dilatation and carotid intima media thickness in young nonobese polycystic ovary syndrome patients: existence of insulin resistance alone may not represent an adequate condition for deterioration of endothelial function

3 12 2008

To the Editor:

A recent publication entitled “The evaluation of endothelial function with flow mediated dilatation and carotid intima media thickness in young nonobese polycystic ovary  syndrome patients: existence of insulin resistance alone may not represent an adequate condition for deterioration of endothelial function” (1) has shown that flow mediated dilatation (FMD) was not different between polycystic ovary syndrome (PCOS) and ovulatory women. The FMD in PCOS women was 24.88±9.63% and 22.35±9.40% in the control group. Comparing the values for basal brachial arterial diameter (3.54±0.37 mm and 3.81±0.66 mm; PCOS and control group, respectively) and stimulated brachial arterial diameter (4.41±0.39 mm and 4.65±0.77 mm) the observed dilation was really larger than 20% for both groups. However, the expected FMD in healthy people is 7% to 10%, while the expected FMD in patients with cardiovascular disease is 0 to 5% (2). Furthermore, the great majority of studies evaluating healthy people reported mean FMD between 3% and 15% (3). Read the rest of this entry »





Association of sperm apoptosis and DNA ploidy with sperm chromatin quality in human spermatozoa

3 12 2008

To the Editor:

We read with interest the recent article by Mahfouz et al. (1), and we have some observations.

First, the authors concluded that after semen processing, “the incidence of late apoptotic sperm remains unchanged.” This finding is not consistent with previous studies (2,3) and our recent report (4). The authors found the percentage of non-necrotic sperm (PI negative sperm) to be 63.1% in neat semen and 66.9% after density-gradient separation. In other words, the semen processing provided a sample with one third of PI positive (necrotic) sperm. Thus, assuming that necrotic sperm are immotile, the mean motility after semen processing was less than 67%. This is a surprising result, since the efficiency of density-gradient separation is usually much higher. In fact, the authors report that the sperm motility was significantly improved in all the samples after density-gradient separation. In our recent study, we found a significantly lower percentage of necrotic sperm in the capacitated fraction (8.4%) compared with neat semen (13.1%). Read the rest of this entry »