Letrozole monotherapy in the treatment of uterine myomas

27 01 2010

To the Editor:

We read with great interest the manuscript by Parsanezhad et al. (1), which reports the results of a prospective, multicenter, randomized, assessor-blind trial comparing the effects of letrozole and triptorelin on uterine myoma volume. The investigators should be congratulated on their observation that the administration of letrozole reduced myoma volume without determining systemic hypoestrogenism. We would like to bring to your attention some details of the study, which may be relevant in the understanding of the use of aromatase inhibitors in premenopausal women. Read the rest of this entry »

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Coasting resulting in a sharp decline in serum estradiol does not compromise implantation

25 01 2010

To the Editor:

We read the retrospective analysis of Abdalla and Nicopoullos (1) with great interest. We agree with the results, especially regarding the effects of estradiol drop (E2d). As was previously mentioned in the early studies, no strict, evidence-based criteria were established regarding the initial estradiol level (E2i) to start coasting that would not compromise oocyte/embryo quality or implantation capacity of the embryos. Read the rest of this entry »





Calling attention to the use of false “endothelial” cell lines.

7 01 2010

To the Editor:

In the article authored by Berlado Andozia et al. published online 11 November 2009 (1), they used the cell line ECV304 as a “human endothelial cell line.” Read the rest of this entry »





Premature luteinization defined by an increased P/E2 ratio on hCG day is a manifestation of diminished ovarian responsiveness to controlled ovarian hyperstimulation.

4 01 2010

To the Editor:

We read with much interest the study of Lai et al. published recently in the Journal (1). We were pleased to notice that our definition of premature luteinization (PL) employing the progesterone/estradiol (P/E2) ratio, on the day of hCG administration (hCG day), in controlled ovarian hyper-stimulation (COH) cycles (2, 3,) is continuing to trigger a debate. Read the rest of this entry »