Does Tranvaginal Ultrasound Guidance Have a Role in Embryo Transfers?

30 09 2010

To the Editor:

We read the Modern Trends paper by Mains and Van Voorhis (1) in the August issue on “Optimizing the technique of embryo transfer” with great interest. Mains and Van Voorhis eloquently reviewed the evidence that certain methods in the embryo transfer (ET) are associated with improved outcomes after IVF, dispelling the historical notion that ET is an unimportant variable in the success of an ART treatment cycle (1). As such, they contend that there is no consensus on the optimal technique of ET. Read the rest of this entry »

AMH and Repetitive Oocyte Donation

27 09 2010

To the Editor:

The data that Bukulmez et al. present on increases in AMH with each oocyte donation cycle (Figure 2) is unexpected and provocative (1). The increase appeared to be most pronounced when donation cycles occurred in rapid succession, as demonstrated most convincingly in Group 6. The increase could be due to FSH stimulation of preantral and early antral follicles, the follicular stages that produce the most AMH (2). Read the rest of this entry »

Estrogen-vitamin D interaction in multiple sclerosis

24 09 2010

To the Editor:

We read with interest the recently published article showing that women who had been using combined oral contraceptives and/or had given birth prior to the onset of multiple sclerosis (MS) had a higher mean age of onset of the disease (1). The authors speculate that estrogen levels are likely to influence MS onset through an effect on the immune system. Read the rest of this entry »

A critical look at the evidence does not support PGD for translocation carriers with a history of recurrent losses

1 09 2010

To the Editor:

We read with interest the article by Fischer et al. which present a retrospective review of data on the effect of preimplantation genetic diagnosis (PGD) for carriers of a translocation with a history of three or more pregnancy losses (1). The authors conclude that PGD improves pregnancy outcome and dramatically reduces time to conceive. However, their data and comparative analysis did not convince us that their conclusions are justified, as outlined below. Read the rest of this entry »