Luteinizing hormone surge in normally ovulating women

21 01 2013

To the Editor:

After reading the article “Relationships between the luteinizing hormone surge and other characteristics of the menstrual cycle in normally ovulating women” (1), now including concurrent ultrasound data I would like to confirm once more hormonal findings published in Fertility and Sterility more than a decade ago (2). Unnoticed, Park et al. also described these LH patterns in your journal in 2007 (3).

I have reanalyzed the data published originally (2), according to the methods specified in the studies by Direito et al. and Park et al. (1, 3), and shown data from all three studies in Tables 1 and 2. The sum (25%) of what was first described as two peaks and a small peak (2) would be comparable herein to a double peak. Park et al. found a luteinizing hormone (LH) surge of rapid onset (within 1 day) in 42.9% of patients, and of gradual onset (in 2 to 6 days) in 57.1%, or 25.6% and 74.4% in 2 to 10 days, respectively. Overall, although in some cases there seemed to be a tendency, after analyzing three or more cycles from each woman, I did not clearly find repetition of the same type of LH profile within the same woman reported by Direito et al. Relating LH and Pregnanediol Glucuronide (PDG) profiles, a novel finding is that cases with double- and multiple-peaked LH surges associated significantly with transient rises in PDG before the definite rise (P<0.001, Chi test; PDG rise according to Park et al.). Read the rest of this entry »

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Letter on assessing research quality in major infertility journals

17 01 2013

To the editor:

We read with great interest the article by Glujovsky et al. (1), followed by the editorial comment of Dr. Legro (2), evaluating the level of evidence published in five infertility journals with a high impact factor. Authors concluded that both systematic reviews with meta-analysis (SRs) and randomized controlled trials (RCTs) were published at a disappointingly low level of 1.5 and 6.8%, respectively, with 15% of them multicenter RCTs. More than 90% of all the publications in the top five journals were neither SRs nor RCTs.

Our thought is on the mixture of positive and negative impact of the current finding. Read the rest of this entry »