Should early cleavage (EC) be assessed in routine practice?

28 02 2014

To the Editor:

In a recent study (1), an important question has been mooted, namely, “Should we assess early cleavage between 25 to 27 hours after insemination, with the aim of yielding any benefit in the clinical outcomes?” The message I have been delivered by the results has been, “There was not any benefit of early cleavage assessment, unless all transfer embryos were of sub-optimal quality.” Promoted by ASEBIR with a clear aim to conclude with a scientifically based recommendation to embryologists, I think the results need to be evaluated under scrutiny. Read the rest of this entry »

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Male infertility biomarkers and genomic aberrations in azoospermia

17 02 2014

To the Editor:

Estimates indicate that 15-30% (or more) of male infertility is due to whole-organism genetic abnormalities with large numbers of genes already discovered to play important roles (1, 2). Numerous methods have yielded new genetic discoveries with the karyotype, fluorescent in situ hybridization, comparative genomic hybridization and microarrays all contributing (1). All identified genetic aberrations are further complicated by epigenetic modifications (i.e., methylation and protamination), as well as individual differences and environmental influences that make diagnosis and treatment frustrating (1). Unfortunately, in many men, the result of multiple investigations often yields inconclusive, or slightly abnormal results, with a subsequent diagnosis of idiopathic infertility. Read the rest of this entry »