Ovarian Hyperstimulation Syndrome in a Patient Treated with Tamoxifen for Breast Cancer

9 06 2011

To the Editor:

I read with great interest the case report by Baigent and Lashen (1) describing a case of bilateral ovarian cysts induced by tamoxifen therapy for breast cancer in a 50-year-old woman. The authors performed laparoscopic bilateral salpingo-oophorectomy to enable a histological examination as well as eliminate the source of estrogen.

We have already described ovarian cysts in 80% out of twenty premenopausal breast cancer tamoxifen-treated patients accompanied by high levels of estradiol. At the same time, these findings were found in only one (out of 12) similar patients not treated with tamoxifen (2). Read the rest of this entry »

Ovarian reserve and oocyte maturity in cancer patients

17 05 2011

To the Editor:

With great interest we read the article on ovarian reserve and oocyte maturity in cancer patients undergoing in vitro maturation treatment (IVM) by Moria et al. (1). Detailed information concerning this topic is of great value to doctors counselling cancer patients with regard to their wish to conceive in the (near) future.

The authors studied ovarian reserve and oocyte maturity in cancer patients in comparison to infertile patients (1). We wonder whether it is correct to compare cancer patients to infertile patients. Ideally, one would like to compare to healthy subjects to investigate the effect of cancer on fertility. We are aware that it would be ethically impossible to acquire these parameters on a group of fertile individuals as they would have to undergo unnecessary IVM. However, a viable solution to this problem would be to compare cancer patients with couples who are infertile due to an andrological factor. Read the rest of this entry »

Use of the levonorgestrel-releasing intrauterine system in breast cancer patients

9 12 2008

To the Editor:

The observational study by Trinh et al.(1) concludes that there is a higher recurrence rate when breast cancers are detected during the use of a LNG-IUS and when it is not removed after diagnosis. Although the authors mainly generate several hypotheses around their observations, we would like to warn about  inappropriate interpretation of their data and premature conclusions, as such a message was released in a couple of Belgian newspapers recently.(2) Read the rest of this entry »