Five-day anastrozole in infertility needs supplemental hCG

19 05 2011

To the Editor:

I read with great interest the article by Tredway D et al. (1), in which they concluded that “in terms of ovulation rates, 5-day anastrozole at 1,5, and 10 mg/d was less effective than CC at 50mg/d for cycle 1”. They have done a good work.

However, surprisingly, the ovulation rates for anastrozole groups were obviously low. In their Results Section, they mentioned that “most patients receiving anastrozole 1 mg/d (72.7%) and 5 mg/d (73.5%) achieved monofollicular development (one follicle ≥ 17 mm in diameter), compared with 70.4% of patients receiving CC”. We argue that monofollicular development (one follicle ≥ 17 mm in diameter) rates were similar between anastrozole and CC, why was ovulation rates difference so significant (the ovulation rates for anastrozole at 1, 5, and 10 mg/d were 30.4%, 36.8% and 35.9%, respectively, compared with 64.9% for CC at 50 mg/d)?

We believe that it is due to lack of supplemental hCG. Read the rest of this entry »


Suggestion and comment for CC preventing LH surge

30 03 2011

To the Editor:

I read with interest the article by Al-Inany et al. (1) in which the authors demonstrated the beneficial effects of the addition of clomiphene citrate (CC) to human menopausal gonadotropin (hMG) during intrauterine insemination (IUI) cycles to prevent a premature luteinizing hormone (LH) surge. Their study was well designed. Surprisingly, the endometrial thickness of both groups w thin, with an average thickness of less than 6.0 mm, which may reduce pregnancy rates as the authors mentioned. Read the rest of this entry »

Protocol for luteal-phase clomiphene citrate in women with PCOS

16 07 2009

To the Editor:

It was an interesting article by Badawy et al. on luteal-phase clomiphene citrate (1). There were two points on which I would like to request clarification.
Read the rest of this entry »

Reassurance of safety of letrozole and suggested approaches in controlled ovarian hyperstimulation

30 03 2009

To the Editor:

We read the article by Dr. Dickey with interest (1). Although it covers many aspects of ovulation induction and related multiple pregnancies, we believe some points require further comment. Read the rest of this entry »