Estrogen-vitamin D interaction in multiple sclerosis

24 09 2010

To the Editor:

We read with interest the recently published article showing that women who had been using combined oral contraceptives and/or had given birth prior to the onset of multiple sclerosis (MS) had a higher mean age of onset of the disease (1). The authors speculate that estrogen levels are likely to influence MS onset through an effect on the immune system. Read the rest of this entry »

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Ovarian steroid hormones differentially regulate thrombospondin-1 expression

12 03 2010

To the Editor:

We read with great interest the article of Tan et al. (1) which reported that thrombospodin-1 (TSP-1), a multifunctional extracellular naturally occurring angiostatic protein is differentially regulated by ovarian steroids. Although it is of great clinical value to understand the mechanism(s) involved in TSP-1 regulation by ovarian steroidal hormones especially in relation to how it is involved in endometriosis. However, there are some points we would like to raise regarding the study of Tan et al. (1). Read the rest of this entry »





Endometrial preparation for in vitro maturation treatment

27 10 2009

To the Editor:

We read with great interest the paper published recently by Elizur et al. in the September 2009 edition of Fertility and Sterility (1). The authors compared retrospective data of two different protocols used to perform in vitro maturation treatment (IVM) based on physician preference: only micronized 17β-estradiol (6-12 mg/day) for endometrial preparation or human menopausal gonadotropins (HMG) 150 IU/day to induce both endometrial preparation and mild follicle stimulation. Read the rest of this entry »