IVM media are designed specifically to support immature cumulus-oocyte complexes not denuded oocytes that have failed to respond to hyperstimulation

2 06 2011

To the Editor:

We wish to express concern about the design, analysis and conclusions reported in the article by Moschini et al. (1). This study compares the efficiency of an oocyte IVM medium (Medicult) to a cleavage-stage embryo culture medium (Sage IVF), for the in vitro maturation (IVM) of denuded oocytes that have failed to respond to gonadotropins in a standard IVF cycle (rescue IVM). We have a number of objections to this study: Read the rest of this entry »





Ovarian reserve and oocyte maturity in cancer patients

17 05 2011

To the Editor:

With great interest we read the article on ovarian reserve and oocyte maturity in cancer patients undergoing in vitro maturation treatment (IVM) by Moria et al. (1). Detailed information concerning this topic is of great value to doctors counselling cancer patients with regard to their wish to conceive in the (near) future.

The authors studied ovarian reserve and oocyte maturity in cancer patients in comparison to infertile patients (1). We wonder whether it is correct to compare cancer patients to infertile patients. Ideally, one would like to compare to healthy subjects to investigate the effect of cancer on fertility. We are aware that it would be ethically impossible to acquire these parameters on a group of fertile individuals as they would have to undergo unnecessary IVM. However, a viable solution to this problem would be to compare cancer patients with couples who are infertile due to an andrological factor. Read the rest of this entry »





It ain’t necessarily so…

17 09 2009

To the Editor:

I have read with interest the case report by Azem et al. (1), and congratulate them. However, several points need clarification:
Read the rest of this entry »





IVM of immature oocytes in stimulated cycles

13 04 2009

Johnson et al’s (1) efforts to rescue and utilize immature oocytes generated during ovarian stimulation cycles which would otherwise be wasted are commendable. This author’s experience in a similar endeavor (2) suggests that ovarian stimulation regimes may generate approximately 20% immature oocytes (1, 2), which is a significant loss if efforts are not made to rescue and utilize them. Read the rest of this entry »





Effect of a phosphodiesterase type 3 inhibitor in oocyte maturation medium on subsequent mouse embryo development

30 10 2008

To the Editor:

Jee et al. (1) report that in their hands a prematuration culture using a phosphodiesterase type 3 (PDE3) inhibitor does not improve developmental competence of immature oocytes. We and others previously reported a beneficial effect of this system (2-6). Fundamental differences in experimental design between their work and ours may explain this discrepancy. Read the rest of this entry »