Inositol effects on ovulation induction in patients with polycystic ovary syndrome.

28 03 2011

To the Editor:

I read with interest the recent paper of Morgante et al (1) describing positive effects of Inositol in increasing insulin sensitivity in patients with polycystic ovary syndrome (2), confirming the concept that insulin-sensitizer molecules alone or in combination with clomiphene citrate or gonadotrophin, somehow ameliorates ovulation in such patients.

However some comments on both design and results of the study are necessary for a critical view of potential clinical application of inositol in ART. Read the rest of this entry »





Dehydroepiandrosterone sulfate and insulin resistance in patients with polycystic ovary syndrome

30 01 2009

To the Editor:

We would like to thank Dr. Brennan et al for their fine article (1). In this study, they found that dehydroepiandrosterone (DHEAS) was negatively correlated to insulin resistance in patients with polycystic ovary syndrome (PCOS) and the independent variables that affect the insulin resistance, in decreasing importance, were body mass index (BMI), waist-to-hip ratio (WHR), age, DHEAS, free testosterone (T), sex hormone binding globulin (SHBG) and 17-hydroxyprogesterone (17-OHP). Read the rest of this entry »





The evaluation of endothelial function with flow mediated dilatation and carotid intima media thickness in young nonobese polycystic ovary syndrome patients: existence of insulin resistance alone may not represent an adequate condition for deterioration of endothelial function

3 12 2008

To the Editor:

A recent publication entitled “The evaluation of endothelial function with flow mediated dilatation and carotid intima media thickness in young nonobese polycystic ovary  syndrome patients: existence of insulin resistance alone may not represent an adequate condition for deterioration of endothelial function” (1) has shown that flow mediated dilatation (FMD) was not different between polycystic ovary syndrome (PCOS) and ovulatory women. The FMD in PCOS women was 24.88±9.63% and 22.35±9.40% in the control group. Comparing the values for basal brachial arterial diameter (3.54±0.37 mm and 3.81±0.66 mm; PCOS and control group, respectively) and stimulated brachial arterial diameter (4.41±0.39 mm and 4.65±0.77 mm) the observed dilation was really larger than 20% for both groups. However, the expected FMD in healthy people is 7% to 10%, while the expected FMD in patients with cardiovascular disease is 0 to 5% (2). Furthermore, the great majority of studies evaluating healthy people reported mean FMD between 3% and 15% (3). Read the rest of this entry »





Oligo-ovulation or anovulation and hyperandrogenemia contribute to the decreased serum adiponectin levels in normal weight women with PCOS, besides obesity and insulin resistance.

3 11 2008

To the Editor:

We have read with great interest the excellent and well-designed study by Aroda et al. (1). We would like to comment on the potential relationship between serum adiponectin levels, obesity and insulin resistance (IR) in women with polycystic ovary syndrome (PCOS).  Read the rest of this entry »