Androgen pre-treatment in poor responders undergoing controlled ovarian stimulation and IVF treatment

25 04 2011

To the Editor:

We updated our meta-analysis (1) following the recent publication of a randomized controlled trial (RCT) evaluating the effect of testosterone pre-treatment in poor responders undergoing IVF treatment (2).

Our updated meta-analysis of RCTs of adjuvant androgens [DHEA (dehydroepiandrosterone) and testosterone] in poor responders showed a significant improvement in the ongoing pregnancy/ live birth rates (RR 2.08; 95% CI: 1.10, 3.93; p = 0.002, Figure 1). Meta-analysis for the outcome of total dose of gonadotrophin consumption showed a significantly lower gonadotrophin consumption in the androgen supplementation group compared to the control group (WMD -464.66; 95% CI: – 612.90 to -312.42; p < 0.01, Figure 2). Read the rest of this entry »