Ovarian Hyperstimulation Syndrome in a Patient Treated with Tamoxifen for Breast Cancer

9 06 2011

To the Editor:

I read with great interest the case report by Baigent and Lashen (1) describing a case of bilateral ovarian cysts induced by tamoxifen therapy for breast cancer in a 50-year-old woman. The authors performed laparoscopic bilateral salpingo-oophorectomy to enable a histological examination as well as eliminate the source of estrogen.

We have already described ovarian cysts in 80% out of twenty premenopausal breast cancer tamoxifen-treated patients accompanied by high levels of estradiol. At the same time, these findings were found in only one (out of 12) similar patients not treated with tamoxifen (2). Read the rest of this entry »

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IVM media are designed specifically to support immature cumulus-oocyte complexes not denuded oocytes that have failed to respond to hyperstimulation

2 06 2011

To the Editor:

We wish to express concern about the design, analysis and conclusions reported in the article by Moschini et al. (1). This study compares the efficiency of an oocyte IVM medium (Medicult) to a cleavage-stage embryo culture medium (Sage IVF), for the in vitro maturation (IVM) of denuded oocytes that have failed to respond to gonadotropins in a standard IVF cycle (rescue IVM). We have a number of objections to this study: Read the rest of this entry »





Defining Case Control Studies

6 04 2011

We read with great interest the article “Obstetric outcome of women with in vitro fertilization pregnancies hospitalized for ovarian hyperstimulation syndrome: a case-control study” by Courbiere et al. (1). It is our belief that, despite the title, the study did not adhere to the principles of a case-control study. Read the rest of this entry »





Endocrine gland – derived vascular endothelial growth factor concentrations in follicular fluid and Serum may predict ovarian hyperstimulation syndrome

17 03 2011

To the Editor:

We read with great interest the article of Gao et al. (1). Gao et al. (1) had 17 patients that showed only mild to moderate signs and symptoms of OHSS using Golan classification system (2). A more recent classification reclassified OHSS into two groups (moderate and severe) stressing that mild OHSS signs are seen in most cases of controlled ovarian hyperstimulation that does not require special treatments (3), further reducing their OHSS patients number. Therefore, in the absence of severe OHSS cases, it is possible that the signs and symptoms of OHSS patients in their study may be similar to the non-OHSS group. Read the rest of this entry »





Coasting resulting in a sharp decline in serum estradiol does not compromise implantation

25 01 2010

To the Editor:

We read the retrospective analysis of Abdalla and Nicopoullos (1) with great interest. We agree with the results, especially regarding the effects of estradiol drop (E2d). As was previously mentioned in the early studies, no strict, evidence-based criteria were established regarding the initial estradiol level (E2i) to start coasting that would not compromise oocyte/embryo quality or implantation capacity of the embryos. Read the rest of this entry »