Haplotypes and polymorphisms of the ANXA5 nontranslated region in Japanese and European women with recurrent miscarriage and in controls

9 10 2013

To the Editor:

Yuko Hayashi and coauthors confirm single nucleotide polymorphism (SNP) rs1050606 (SNP5) of the nontranslated region of the ANXA5 gene as a risk factor for recurrent miscarriage (RM) in Japanese patients (1). They also conclude that the risk allele has no influence on pregnancy outcome from 79 abortions that occurred from November 2012 to February 2013 in a group of 264 Japanese women with RM history in Nagoya City University Hospital. Almost two-thirds of the 79 aborted fetuses, or ~ 64% had abnormal karyotypes, which leaves only n = 17 cases possibly influenced by thrombophilia through carriage of common ANXA5 SNPs/haplotypes, among other factors. Moreover, since no data about the timing of miscarriages are shared, but the majority of abortions in the patient group are apparently due to chromosomal aberrations, it is rather likely this is an early (predominantly before 10th week of gestation) RM group. It is certainly very plausible that live birth rates in such a preselected cohort would not be notably influenced by carriage of ANXA5 SNPs/haplotypes, as M2/ANXA5 for example should not be significant as a risk factor before weeks 10 to 12 of gestation (2). Read the rest of this entry »


A critical look at the evidence does not support PGD for translocation carriers with a history of recurrent losses

1 09 2010

To the Editor:

We read with interest the article by Fischer et al. which present a retrospective review of data on the effect of preimplantation genetic diagnosis (PGD) for carriers of a translocation with a history of three or more pregnancy losses (1). The authors conclude that PGD improves pregnancy outcome and dramatically reduces time to conceive. However, their data and comparative analysis did not convince us that their conclusions are justified, as outlined below. Read the rest of this entry »

It’s time to respect the ASRM definition of recurrent pregnancy loss

9 06 2010

To the Editor:

We read with great interest the article by Jaslow et al. (1). They proposed to determine whether the frequency of abnormal results for evidence-based diagnostic tests differed among women with recurrent pregnancy loss (RPL) based on the number of prior losses (N = 2, 3, or >4). Read the rest of this entry »

Apolipoprotein E4 and recurrent pregnancy loss: Is it time to draw a conclusion?

7 12 2009

To the Editor:

Lately, Bianca et al. revealed a negative association of apolipoprotein E4 (APOE4 ε) allele with recurrent pregnancy loss (RPL) (1), which was against the conclusion drawn by a previous study (2). The contradictory results lead us to believe that it is still too early to draw a conclusion about the association between APOE4 ε and RPL.
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Association of the protein Z intron F G79A gene polymorphism with recurrent pregnancy loss

17 12 2008

To the Editor:

We have read with great interest the study by Dossenbach-Glaninger et al demonstrating a significant association between the protein-Z (PZ) intron 79G allele and recurrent pregnancy loss (1). In a recent study of 51 women with recurrent early pregnancy loss vs. 47 control women with at least one successful pregnancy and no spontaneous abortions, this finding was not confirmed (2); however, a significant association between low PZ levels and recurrent pregnancy loss was observed, in agreement with a previous larger-scale study (3). Read the rest of this entry »