Systemic Methotrexate Treatment Under the Spotlight in Cervical Ectopic Pregnancies

Verma and colleague recently described a safe and viable noninvasive method of managing cervical ectopic pregnancies.(1) This report takes the management of this potentially life-threatening disease a significant step forward by administering systemic methotrexate alone or in a combination with ultrasound-guided potassium chloride (KCl) into the fetal heart.

Parity and Subfertility Effects of Continuous Oral Contraceptives on Fertility Are Important

To the Editor:

In recent articles, Barnhart and colleagues present data on time to conception following discontinuation of continuous oral contraception (OC) (1). They compare these and other data and conclude that “the return of fertility in former OC users … is comparable to … other contraceptive methods” (2). While we are pleased to see the addition of empirical evidence to this debate, we have some concerns about the role of parity in the time to conception, and are concerned that an uncritical acceptance of this conclusion may cause harm.

Measures of ovarian function in galactosemia — a response to Gubbels et al.

To the Editor:

We are writing in response to a recent case report by Gubbels and colleagues (1) describing a woman with classic galactosemia who became pregnant shortly after a low anti-mullerian hormone (AMH) blood measurement. The authors contrast their case with results published by our group from a study of 35 galactosemic girls and women (2).

Study Raises Further Questions on the Effectiveness of GnRH Analogs as a Method of Gonadal Protection in Cancer Patients

To the Editor:

While we read the recent manuscript from Badawy et al. (1) with great interest, we have concerns about their interpretation that GnRH analogs (GnRHa) preserve fertility.