To the Editor:
Ovarian cryopreservation appears to hold much promise for fertility preservation of women undergoing gonadotoxic therapy. In the Netherlands, cryopreservation of ovarian tissue has been performed for a number of cancer patients. No autotransplantation of ovarian tissue has been performed thus far, due (amongst other reasons) to concerns about the risk of reintroducing the malignancy with the transplant.
The available literature on this subject is not unequivocal. For example, Shaw et al. (1) have shown in a mouse model that lymphoma can be transmitted to the recipient by both fresh and frozen ovarian tissue grafts. Kim et al. (2), on the other hand, reassuringly demonstrated that none of the mice that were xenografted with human ovarian tissue fragments derived from patients with (non)Hodgkin lymphoma developed disease. Read the rest of this entry »